Assemblée Générale 2015

Signs of serotonin syndrome'

Easily annoyed, Craze, Loss of consciousness, Fits, Restlessness, Increased middle rate, Perspiration, Chill, Tremor, Mental status changes, Restlessness, Increased reflexes, Increased reflexes, Stiffness, Shaking, Pain in the abdomen, Diarrhea, Perspiring, Increased temperature, High blood pressure. All these are signs or symptoms of serotonin syndrome. All may come generally in the first 24 hours soon after taking a great o.d. of serotonin drugs. This signs take cognitive stage, visceral anxious system degree and somatic degree. Serotonin toxicity appear frequently soon after o.d. of serotonin drugs and drug combination that increase synaptic serotonin. Drugs that tend to be know to stimulate high levels of serotonin are: MAOIs, TCAs, SSRIs, SNRIs, Bupropion, Tramadol, Fentany, Oxycodone, Hydrocodone, MDMA, MDA, Pep pill, Sibutramine, Crack, Triptans, LSD, Panax Ginseg, Nutmed, Yohimbe, Syrian Rue, Ritonavir, Granisetron, Olanzapine, Valproate, Buspirone, Li, Linezolid, Dextromethorphan, Risperidone, Trypthophan, L-Dopa, Valproate, Amphetamine. Because serotonin toxidrome it's not tested in the laboratory for diagnosis, signs or symptoms are the one that need seen. The best set of criteria to use to diagnose serotonin toxicity is Hunter Serotonin Toxicity Criteria.

Treatment for serotonin syndrome tend to be as follows: discontinuing drugs which produced the overdose posible and drugs that can contribute administration of serotonin antagonist (eg. cyproheptadine) for sever cases of toxicity for agitation, muscle mass stiffness and also seizure like movements, benzodiazepines (Valium, Ativan) Intra venous fluids Because serotonin syndrome is certainly not simple to diagnose, prevention is wanted for any serotonin drugs mixture of which can lead to serotonin toxicity.

Dunkley, EJ, Isbister, GK, Sibbritt, D, Dawson, AH, Whyte, IM, The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity, QJM 2003; 96:635-642 Prator BC. Serotonin syndrome. J Neurosci Nurs. 2006 Apr;38(2):102-5. Ford MD, Clinical Toxicology. 1st ed. Philadelphia, Pa: WB Saunders; 2001:150, 522, 547, 550.